PDB | 5ek0 Human Nav1.7-VSD4-NavAb
Human Nav1.7-VSD4-NavAb in complex with GX-936.
label Keywords
membrane protein, ion channel, voltage-gated sodium channel, small molecule antagonist, metal transport
event_note Published
11/03/2015
blur_on Resolution
3.53 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide
Original publication
import_contacts Title
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
import_contacts Journal
Science 2015
import_contacts DOI
10.1126/science.aac5464
person Authors
Young, C., Wu, P., Mortara, K., Safina, B.S., Estevez, A., Xie, Z., Dehnhardt, C., Clark, K.R., Ahuja, S., Franke, Y., Grimwood, M., Mukund, S., Brillantes, B., Payandeh, J., Cohen, C.J., Andrez, J.C., Li, J., Khakh, K., Tam, C., Johnson, J.P., Ho, H., Verschoof, H., Sampang, H., Ortwine, D.F., Starovasnik, M.A., Coons, M., Deng, L., Focken, T., Hackos, D.H., Bowman, K.K., Lin, S., Koth, C.M., Chang, E., Sutherlin, D.P., Shriver, S.
copyrightData provided by Research Collaboration for Structural Biology, Young, C., Wu, P., Mortara, K., Safina, B.S., Estevez, A., Xie, Z., Dehnhardt, C., Clark, K.R., Ahuja, S., Franke, Y., Grimwood, M., Mukund, S., Brillantes, B., Payandeh, J., Cohen, C.J., Andrez, J.C., Li, J., Khakh, K., Tam, C., Johnson, J.P., Ho, H., Verschoof, H., Sampang, H., Ortwine, D.F., Starovasnik, M.A., Coons, M., Deng, L., Focken, T., Hackos, D.H., Bowman, K.K., Lin, S., Koth, C.M., Chang, E., Sutherlin, D.P., Shriver, S. , provided free of copyright via the Protein DataBank. View original data or read license terms.
