PDB | 5cxv Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium
label Keywords
acetylcholine, allosteric regulation, carrier proteins, cholinergic antagonists, tiotropium receptor, muscarinic m1, gpcr, subtype selectivity, hydrolase
event_note Published
11/20/2024
blur_on Resolution
2.7 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, CHOLESTEROL HEMISUCCINATE, 1,2-ETHANEDIOL, TRIETHYLENE GLYCOL, GLYCEROL
Original publication
import_contacts Title
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature17188
person Authors
Sexton, P.M., Bachhawat, P., Kobilka, B.K., Sun, B., Weis, W.I., Nawaratne, V., Bures, M.G., Kobilka, T.S., Feng, D., Leach, K., Thal, D.M., Christopoulos, A., Felder, C.C., Evans, D.A.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Sexton, P.M., Bachhawat, P., Kobilka, B.K., Sun, B., Weis, W.I., Nawaratne, V., Bures, M.G., Kobilka, T.S., Feng, D., Leach, K., Thal, D.M., Christopoulos, A., Felder, C.C., Evans, D.A. , provided free of copyright via the Protein DataBank. View original data or read license terms.
