PDB | 5cgd Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
label Keywords
7tm, receptor, gpcr, membrane-protein, signaling protein
event_note Published
11/20/2024
blur_on Resolution
2.603 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
OLEIC ACID, 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile
Original publication
import_contacts Title
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
import_contacts Journal
J.Med.Chem. 2015
import_contacts DOI
10.1021/acs.jmedchem.5b00892
person Authors
Wiggin, G.R., Jazayeri, A., Dore, A.S., Congreve, M., Errey, J.C., Okrasa, K., Serrano-Vega, M.J., Marshall, F.H., Christopher, J.A., Aves, S.J., Tehan, B.G., Bennett, K.A.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Wiggin, G.R., Jazayeri, A., Dore, A.S., Congreve, M., Errey, J.C., Okrasa, K., Serrano-Vega, M.J., Marshall, F.H., Christopher, J.A., Aves, S.J., Tehan, B.G., Bennett, K.A. , provided free of copyright via the Protein DataBank. View original data or read license terms.
