PDB | 5bqh Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain
Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain
label Keywords
mpges-1, enzyme, integral membrane protein, isomerase-isomerase inhibitor complex
event_note Published
03/06/2024
blur_on Resolution
1.601 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
N-[4-(4-chlorophenyl)-1H-imidazol-2-yl]-2-(difluoromethyl)-5-{[(2-methylpropanoyl)amino]methyl}benzamide, GLUTATHIONE, octyl beta-D-glucopyranoside, TETRAETHYLENE GLYCOL, (2-hydroxyethoxy)acetaldehyde
Original publication
import_contacts Title
Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.
import_contacts Journal
J.Med.Chem. 2016
import_contacts DOI
10.1021/acs.jmedchem.5b01249
person Authors
Schiffler, M.A., Woods, T.A., Harvey, A., Yu, X.P., Chandrasekhar, S., Rathmell, R.E., Fisher, M.J., Desai, P.V., Campanale, K.M., Hickey, M.J., York, J.S., Thibodeaux, S.J., Luz, J.G., Jones, S.A., Bhattachar, S.N., Kim, E.J., Antonysamy, S., Condon, B., Seng, T.W., Groshong, C., Norman, B.H., Kuklish, S.L., Hughes, N.E., Rizzo, J.R.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Schiffler, M.A., Woods, T.A., Harvey, A., Yu, X.P., Chandrasekhar, S., Rathmell, R.E., Fisher, M.J., Desai, P.V., Campanale, K.M., Hickey, M.J., York, J.S., Thibodeaux, S.J., Luz, J.G., Jones, S.A., Bhattachar, S.N., Kim, E.J., Antonysamy, S., Condon, B., Seng, T.W., Groshong, C., Norman, B.H., Kuklish, S.L., Hughes, N.E., Rizzo, J.R. , provided free of copyright via the Protein DataBank. View original data or read license terms.
