PDB | 4zjc Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
label Keywords
orexin, suvorexant, sb-674042, membrane protein-transferase complex, signaling protein
event_note Published
10/16/2024
blur_on Resolution
2.832 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
[5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, OLEIC ACID
Original publication
import_contacts Title
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
import_contacts Journal
Nat.Struct.Mol.Biol. 2016
import_contacts DOI
10.1038/nsmb.3183
person Authors
Winrow, C.J., Clark, L., Coleman, P.J., Shao, Z., Renger, J.J., Yin, J., Gotter, A.L., Roecker, A.J., Harrell, C.M., Rosenbaum, D.M., Brautigam, C.A., Babaoglu, K., Scheuermann, T.H.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Winrow, C.J., Clark, L., Coleman, P.J., Shao, Z., Renger, J.J., Yin, J., Gotter, A.L., Roecker, A.J., Harrell, C.M., Rosenbaum, D.M., Brautigam, C.A., Babaoglu, K., Scheuermann, T.H. , provided free of copyright via the Protein DataBank. View original data or read license terms.
