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      PDB | 4ze3 Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed

      Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with fluconazole

      label Keywords
      fluconazole, cyp51, oxidoreductase-oxidoreductase inhibitor complex, y140h, resistance mutation, oxidoreductase-oxidoreducatse inhibitor complex
      event_note Published
      04/20/2015
      blur_on Resolution
      2.2 Å
      filter_center_focus Method
      X-RAY DIFFRACTION
      add_circle Ligands
      PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL

      Original publication

      import_contacts Title
      Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
      import_contacts Journal
      Sci Rep 2016
      import_contacts DOI
      10.1038/srep26213
      person Authors
      Tyndall, J.D., Wilson, R.K., Monk, B.C., Sagatova, A.A., Sabherwal, M., Keniya, M.V.

      Read article from Sci Rep

      Member of

      copyrightData provided by Research Collaboration for Structural Biology, Tyndall, J.D., Wilson, R.K., Monk, B.C., Sagatova, A.A., Sabherwal, M., Keniya, M.V. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

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