PDB | 4zdy Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed
Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with itraconazole
label Keywords
itraconazole, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, resistance mutation, oxidoreductase-oxidoreductase inhibitor complex
event_note Published
03/13/2024
blur_on Resolution
2.02 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Original publication
import_contacts Title
Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
import_contacts Journal
Sci Rep 2016
import_contacts DOI
10.1038/srep26213
person Authors
Tyndall, J.D., Wilson, R.K., Monk, B.C., Sagatova, A.A., Sabherwal, M., Keniya, M.V.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Tyndall, J.D., Wilson, R.K., Monk, B.C., Sagatova, A.A., Sabherwal, M., Keniya, M.V. , provided free of copyright via the Protein DataBank. View original data or read license terms.
