PDB | 4xdl Human two pore domain potassium ion channel TREK2 (K2P10.1)
Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.
label Keywords
transport protein, outward rectification, membrane protein, k2p, structural genomics, structural genomics consortium, sgc
event_note Published
11/13/2024
blur_on Resolution
3.5 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CADMIUM ION, 3-[2-bromanyl-4-(trifluoromethyl)phenoxy]-N-methyl-3-phenyl-propan-1-amine
Original publication
import_contacts Title
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
import_contacts Journal
Science 2015
import_contacts DOI
10.1126/science.1261512
person Authors
McClenaghan, C., Sansom, M.S., Ruda, G.F., Mukhopadhyay, S., Burgess-Brown, N.A., Grieben, M., Pike, A.C., Mackenzie, A., Dong, Y.Y., Tucker, S.J., Aryal, P., Dong, L., Quigley, A., Clausen, M.V., Carpenter, E.P., Goubin, S., Brennan, P.E., Cao, L.
copyrightData provided by Research Collaboration for Structural Biology, McClenaghan, C., Sansom, M.S., Ruda, G.F., Mukhopadhyay, S., Burgess-Brown, N.A., Grieben, M., Pike, A.C., Mackenzie, A., Dong, Y.Y., Tucker, S.J., Aryal, P., Dong, L., Quigley, A., Clausen, M.V., Carpenter, E.P., Goubin, S., Brennan, P.E., Cao, L. , provided free of copyright via the Protein DataBank. View original data or read license terms.
