PDB | 4u14 Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized
Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)
label Keywords
alpha helix, g protein-coupled receptors (gpcrs), membrane protein, t4 lysozyme, fusion protein, chimera protein
event_note Published
11/06/2024
blur_on Resolution
3.57 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane
Original publication
import_contacts Title
Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.
import_contacts Journal
Structure 2014
import_contacts DOI
10.1016/j.str.2014.08.022
person Authors
Weis, W.I., Matt, R., Thorsen, T.S., Kobilka, B.K.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Weis, W.I., Matt, R., Thorsen, T.S., Kobilka, B.K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
