PDB | 4ret Na,K-ATPase E2P-digox
Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium
label Keywords
alpha-helical transmembrane protein, atpase, sodium ion transport, potassium ion transport, atp binding, sodium binding, potassium binding, receptor for cardiotonic steroids, phosphorylation, glycosylation, plasma membrane, multisubunit complex, trimeric complex, membrane protein, hydrolase-inhibitor complex
event_note Published
09/23/2014
blur_on Resolution
4 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
MAGNESIUM ION, CHOLESTEROL, DIGOXIN, O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine, 2-acetamido-2-deoxy-beta-D-glucopyranose
Original publication
import_contacts Title
Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2015
import_contacts DOI
10.1073/pnas.1422997112
person Authors
Nissen, P., Gregersen, J.L., Laursen, M., Fedosova, N.U., Yatime, L.
copyrightData provided by Research Collaboration for Structural Biology, Nissen, P., Gregersen, J.L., Laursen, M., Fedosova, N.U., Yatime, L. , provided free of copyright via the Protein DataBank. View original data or read license terms.
