PDB | 4qin Structure of the human smoothened receptor
Structure of the human smoothened receptor in complex with SAG1.5
label Keywords
human smoothened receptor, agonist, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, signaling protein
event_note Published
11/20/2024
blur_on Resolution
2.6 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
Original publication
import_contacts Title
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
import_contacts Journal
Nat Commun 2014
import_contacts DOI
10.1038/ncomms5355
person Authors
Urban, D.J., Hufeisen, S.J., Vardy, E., Wang, C., Han, G.W., Evron, T., Roth, B.L., Katritch, V., Mangano, T.J., Wu, H., Caron, M.G., Huang, X.P., Cherezov, V., Stevens, R.C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Urban, D.J., Hufeisen, S.J., Vardy, E., Wang, C., Han, G.W., Evron, T., Roth, B.L., Katritch, V., Mangano, T.J., Wu, H., Caron, M.G., Huang, X.P., Cherezov, V., Stevens, R.C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
