PDB | 4or2 Human class C G protein-coupled metabotropic glutamate receptor 1
Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator
label Keywords
human metabotropic glutamate receptor 1, allosteric modulator, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, signaling protein
event_note Published
11/13/2024
blur_on Resolution
2.8 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
4-fluoro-N-methyl-N-{4-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl}benzamide, CHOLESTEROL, OLEIC ACID, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PHOSPHATE ION
Original publication
import_contacts Title
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
import_contacts Journal
Science 2014
import_contacts DOI
10.1126/science.1249489
person Authors
Xia, Y., Cho, H.P., Wang, C., Gregory, K.J., Han, G.W., Katritch, V., Conn, P.J., Wu, H., Meiler, J., Niswender, C.M., Cherezov, V., Stevens, R.C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Xia, Y., Cho, H.P., Wang, C., Gregory, K.J., Han, G.W., Katritch, V., Conn, P.J., Wu, H., Meiler, J., Niswender, C.M., Cherezov, V., Stevens, R.C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
