PDB | 4mqt Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
label Keywords
g protein-coupled receptor, muscarinic acetylcholine receptor, allosteric modulation, signaling protein
event_note Published
11/06/2024
blur_on Resolution
3.7 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
Original publication
import_contacts Title
Activation and allosteric modulation of a muscarinic acetylcholine receptor.
import_contacts Journal
Nature 2013
import_contacts DOI
10.1038/nature12735
person Authors
Sexton, P.M., Hu, K., Garcia, K.C., Kobilka, B.K., Hubner, H., Eitel, K., Kruse, A.C., Manglik, A., Ring, A.M., Valant, C., Hu, J., Wess, J., Gmeiner, P., Steyaert, J., Weis, W.I., Christopoulos, A., Felder, C.C., Pardon, E.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Sexton, P.M., Hu, K., Garcia, K.C., Kobilka, B.K., Hubner, H., Eitel, K., Kruse, A.C., Manglik, A., Ring, A.M., Valant, C., Hu, J., Wess, J., Gmeiner, P., Steyaert, J., Weis, W.I., Christopoulos, A., Felder, C.C., Pardon, E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
