PDB | 4k5y Human corticotropin-releasing factor receptor 1 (CRF1R)
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
label Keywords
7tm, gpcr, family b, signalling protein, g-protein, membrane, membrane protein, receptor
event_note Published
11/20/2024
blur_on Resolution
2.977 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine, OLEIC ACID, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, SULFATE ION, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, PENTAETHYLENE GLYCOL
Original publication
import_contacts Title
Structure of class B GPCR corticotropin-releasing factor receptor 1.
import_contacts Journal
Nature 2013
import_contacts DOI
10.1038/nature12357
person Authors
Weir, M., Cheng, R.K., Jazayeri, A., Dore, A.S., Kean, J., Cooke, R.M., Bortolato, A., Marshall, F.H., Hollenstein, K.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Weir, M., Cheng, R.K., Jazayeri, A., Dore, A.S., Kean, J., Cooke, R.M., Bortolato, A., Marshall, F.H., Hollenstein, K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
