PDB | 4jkv Structure of the human smoothened 7TM receptor
Structure of the human smoothened 7TM receptor in complex with an antitumor agent
label Keywords
human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane
event_note Published
11/06/2024
blur_on Resolution
2.45 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, OLEIC ACID, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
Original publication
import_contacts Title
Structure of the human smoothened receptor bound to an antitumour agent.
import_contacts Journal
Nature 2013
import_contacts DOI
10.1038/nature12167
person Authors
Cherezov, V., Wang, C., Han, G.W., Katritch, V., Siu, F.Y., Wu, H., Stevens, R.C., Huang, X.P., Roth, B.L., Liu, W.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Cherezov, V., Wang, C., Han, G.W., Katritch, V., Siu, F.Y., Wu, H., Stevens, R.C., Huang, X.P., Roth, B.L., Liu, W. , provided free of copyright via the Protein DataBank. View original data or read license terms.
