PDB | 4j2t Inhibitor-bound Ca2+ ATPase

Inhibitor-bound Ca2+ ATPase

label Keywords
p-type atpase, calcium transport, thapsigargin analog, sarco(endo)plasmic reticulum, hydrolase-hydrolase inhibitor complex
event_note Published
10/16/2024
blur_on Resolution
3.2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3a,4-bis(butanoyloxy)-3-hydroxy-3,6,9-trimethyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION

Original publication

import_contacts Title
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase.
import_contacts Journal
J.Med.Chem. 2013
import_contacts DOI
10.1021/jm4001083
person Authors
Paulsen, E.S., Christensen, S.B., Lie, M.A., Schiott, B., Liu, H., Tenori, E., Sehgal, P., Bonde, D.F., Bublitz, M., Nissen, P., Moller, J.V., Villadsen, J., Dach, I., Autzen, H.E., Olesen, C.

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