PDB | 3vw7 Human protease-activated receptor 1 (PAR1)
Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
label Keywords
high resolution structure, protease-activated receptor 1, inactive conformation, antagonist vorapaxar, g protein-coupled receptor, signaling protein, membrane protein, thrombin receptor-antagonist complex, signaling protein-antagonist complex
event_note Published
11/20/2024
blur_on Resolution
2.2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]fur an-6-yl]carbamate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, SODIUM ION
Original publication
import_contacts Title
High-resolution crystal structure of human protease-activated receptor 1
import_contacts Journal
Nature 2012
import_contacts DOI
10.1038/nature11701
person Authors
Weis, W.I., Srinivasan, Y., Zheng, Y., Kobilka, B.K., Dror, R.O., Zhang, C., Pandey, A., Fung, J.J., Palmer, D., Arlow, D.H., Shaw, D.E., Coughlin, S.R., Green, H.F.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Weis, W.I., Srinivasan, Y., Zheng, Y., Kobilka, B.K., Dror, R.O., Zhang, C., Pandey, A., Fung, J.J., Palmer, D., Arlow, D.H., Shaw, D.E., Coughlin, S.R., Green, H.F. , provided free of copyright via the Protein DataBank. View original data or read license terms.
