PDB | 3vmt Staphylococcus aureus membrane-bound transglycosylase

Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a Lipid II analog

label Keywords
transmembrane, glycosyltransferase, bacterial cell wall synthesis, membrane, transferase
event_note Published
12/15/2011
blur_on Resolution
2.299 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
[(2R,3R,4R,5S,6R)-4-[(2R)-1-[[(2S)-1-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethylamino]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-propan-2-yl]oxy-3-acetamido-5-[(2S,3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxan-2-yl] [oxidanyl(3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenoxy)phosphoryl] hydrogen phosphate, MAGNESIUM ION

Original publication

import_contacts Title
Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2012
import_contacts DOI
10.1073/pnas.1203900109
person Authors
Cheng, T.J.R., Lin, L.Y., Wong, C.H., Tien, Y.W., Huang, C.Y., Shih, H.W., Ma, C., Cheng, W.C.

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