PDB | 2ypt Human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A)
Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A
label Keywords
hydrolase-peptide complex, m48 peptidase, integral membrane protein, prelamin a processing, ageing, progeria
event_note Published
05/08/2024
blur_on Resolution
3.8 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
ZINC ION
Original publication
import_contacts Title
The Structural Basis of Zmpste24-Dependent Laminopathies.
import_contacts Journal
Science 2013
import_contacts DOI
10.1126/SCIENCE.1231513
person Authors
von Delft, F., Pike, A.C.W., Bullock, A.N., Burgess-Brown, N.A., Stansfeld, P.J., Sansom, M.S.P., Dong, Y.Y., Dong, L., Edwards, A.M., Quigley, A., Berridge, G., Carpenter, E.P., Shrestha, L., Bountra, C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, von Delft, F., Pike, A.C.W., Bullock, A.N., Burgess-Brown, N.A., Stansfeld, P.J., Sansom, M.S.P., Dong, Y.Y., Dong, L., Edwards, A.M., Quigley, A., Berridge, G., Carpenter, E.P., Shrestha, L., Bountra, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
