PDB | 2by4 SR Ca(2+)-ATPase in the HnE2 state complexed
SR Ca(2+)-ATPase in the HnE2 state complexed with the thapsigargin derivative Boc-12ADT.
label Keywords
serca, p-type atpase, ca2+-atpase, thapsigargin, prostate cancer, atp-binding, calcium, calcium transport, endoplasmic reticulum, hydrolase, ion transport, magnesium, metal-binding, multigene family, nucleotide-binding, phosphorylation, sarcoplasmic reticulum, transmembrane, transport
event_note Published
11/06/2024
blur_on Resolution
3.3 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL 12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, SODIUM ION
Original publication
import_contacts Title
Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells
import_contacts Journal
Bioorg.Med.Chem. 2006
import_contacts DOI
10.1016/J.BMC.2005.12.001
person Authors
Christensen, S.B., Denmeade, S.R., Isaacs, J.T., Soehoel, H., Jensen, A.L., Nissen, P., Moller, J.V., Olsen, C.E.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Christensen, S.B., Denmeade, S.R., Isaacs, J.T., Soehoel, H., Jensen, A.L., Nissen, P., Moller, J.V., Olsen, C.E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
